A team from Baylor College of Medicine and Texas Children's Cancer Center led the study, which tested chimeric antigen receptor (CAR) T cells enhanced with the protein interleukin-15 (IL-15).

Evaluation of: Waldmann TA, Conlon KC, Stewart DM et al. Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-β-1 mAb in patients with T-cell large granular lymphocytic leukemia.

Data obtained in mice and humans revealed that when muscles contract repeatedly and intensely, certain mechanisms kick into place to trigger the production of a protein called IL-15. This protein ...

Hu-Mikβ1 is a humanized antibody to the IL-2/IL-15Rβ receptor and was shown to block IL-2- and IL-15-driven cell proliferation in preclinical models and patient leukemic cells. Hu-Mikβ1 was ...