Recognition of specific antigen through the B-cell receptor (BCR ... in response to which pre-existing natural IgM antibodies could facilitate the rapid formation of immune complexes, thereby ...

They recombinantly expressed an IgM that binds to ganglioside GM3 and kills GM3 positive human myeloma cells in the presence of complement. The hexameric form without J-chain and the pentameric form ...

The development of B cells relies on an intricate network of transcription factors critical for developmental ... Serum Ig was detected using a secondary HRP-conjugated anti-mouse IgM (Southern ...

This important study explores the conserved role of IgM in both systemic and mucosal antiviral immunity in teleosts, challenging established views on the differential roles of IgT and IgM. The ...

The efficacy of CD19-CAR T-cell therapy is presumably based on deep tissue depletion of B cells; however, such effect has not been proven in humans in vivo. Methods Sequential ultrasound-guided ...

The ability to efficiently isolate antigen-specific B cells in ... to remove cell aggregates. The second filtration was done immediately prior to sorting. Prior to sorting, an appropriate number of ...

Intravascular large B-cell lymphoma (IVLBCL) is a rare type of non-Hodgkin’s lymphoma. Its symptoms can vary, making it difficult to diagnose. The outlook for people with IVLBCL is typically poor.

Here, we review the ongoing developments with CAR T cells in the field of autoimmune disorders. We will cover first clinical results of applying anti-CD19 and anti-B cell maturation antigen CAR T ...