Psychology Today6 天
Bystander Effect
Social psychologists Bibb Latané and John Darley popularized the concept of the bystander effect following the infamous murder of Kitty Genovese in New York City in 1964. The 28-year-old woman ...
腾讯网14 天
HER3 ADC+PD-L1+VEGF，治疗晚期实体瘤
来源：CDE 官网 SHR-A2009 是恒瑞医药自主研发的一款靶向 HER3 的 ADC 药物，可特异性结合肿瘤细胞表面上的 HER3，进而被内吞至细胞内并转运至溶酶体中 ...
搜狐14 天
HER3 ADC+PDL1+VEGF！恒瑞新联合疗法获批临床
来源：CDE 官网 SHR-A2009 是恒瑞医药自主研发的一款 靶向 HER3 的 ADC 药物，可特异性结合肿瘤细胞表面上的 HER3，进而被内吞至细胞内并转 运至溶酶体中，水解释放游离毒素，杀伤肿瘤细胞。该产品目前正在开展多项单药临床研究，以及联合阿得贝利单抗或者 ER ...
pharmaphorum1 天
BMS bolts on SystImmune bispecific ADC in $8.4bn deal
In the latest recitation, Bristol-Myers Squibb is paying $800 million upfront for rights to a HER3-directed ADC from China’s SystImmune in a deal that could swell to $8.4 billion. It gives BMS ...
搜狐14 天
新抗癌组合：HER3 ADC、PD-L1和VEGF或成晚期实体瘤治疗新希望
SHR-A2009是一种靶向HER3的ADC药物，它通过特异性结合在肿瘤细胞表面表达的HER3，迅速被细胞摄取，随后转运至溶酶体内，释放毒素以精准杀伤肿瘤细胞。当前，这款药物正在进行多项临床研究，探讨其单独或与阿得贝利单抗及ER降解剂HRS-8080联合使用的效果。
pharmaphorum2 天
AZ and Daiichi's TROP2 ADC shows promise in first-line lung cancer
The HER3-directed ADC will be tested in patients whose disease had progressed despite earlier treatment with EGFR inhibitors, including third-generation drugs like AZ's Tagrisso (osimertinib).