Global Primary Hepatocytes Market Value to Rise Through 2034 with Advancement of Liver Cell-based AssaysRockville, MD, Feb. 05, 2025 (GLOBE NEWSWIRE) -- In 2019, the net worth of the global primary ...

The discovery that RIPK1 deficiency sensitizes the liver to acute injury and hepatocyte apoptosis is based on convincing evidence, highlighting the importance of RIPK1 in maintaining liver homeostasis ...

ZJU-Hangzhou Global Scientific and Technological Innovation Canter, Zhejiang University, Hangzhou, Zhejiang 311215, China College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, ...

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown. Here, we report ...

and resident Kupffer cells (blue) and from injured hepatocytes (green). Oxidative stress, cytokine release, endotoxin, and ethanol and its metabolites can stimulate paracrine chemokine secretion ...

Metabolic requirements of dividing hepatocytes are prerequisite for liver regeneration after injury. In contrast to transcriptional dynamics during liver repair, its metabolic dependencies remain ...

In summary, the expression of ferroptosis markers GPX4 and SLC7A11 is regulated by the AKT/GSK3β/β-catenin signaling pathway, and PFOA may promote hepatocyte ferroptosis by inhibiting this pathway.

In the liver, senescence impacts key cell types including hepatocytes, liver sinusoidal endothelial cells, and Kupffer cells, and contributes to chronic liver diseases such as fibrosis ...

3D validated cells Duo-culture Primary human hepatocytes + Kupffer Cells HBV, DILI, Immune-mediated toxicity PhysioMimix OOC, Liver plates, 3D validated cells Tri-culture Primary human hepatocytes ...