为解决多发性骨髓瘤（multiple myeloma）这一无法治愈的血液恶性肿瘤的治疗难题，研究人员开展了针对新型 SLAMF7 启动子驱动的溶瘤腺病毒（Ad [CE1A]）的研究。结果显示 Ad [CE1A] 在体内外均展现抗骨髓瘤疗效，联合治疗可增强效果。这为骨髓瘤治疗提供了新方向。

School of Pharmaceutical Science and Technology, Tianjin University, 92 Weijin Road, Nankai District, Tianjin 300072, China ...

通派（上海）生物科技有限公司提供各类国内外来源细胞株/系现货近1000+（如ATCC细胞，Sciencell细胞，DSMZ细胞，JCRB细胞，RIKEN ...

研究结果 GLUT9 的功能和结构表征：通过在 HEK293A 细胞中瞬时表达 GLUT9 的两种异构体，评估放射性标记的 [8-14 C]- 尿酸的细胞摄取情况，发现两种异构体均有显著的尿酸摄取活性，且 GLUT9 介导的尿酸摄取不受常用 GLUT 抑制剂细胞松弛素 B 的抑制，但能被苯溴马隆 ...

1． 吸出原培养瓶中的培养基，PBS 缓冲液润洗细胞两次，加 2-3 ml 0.25% 胰_酶进行消化细胞（注意把握消化时间，通常控制在 1-2min） 2． 镜下观察消化情况，在细胞边缘缩小，贴壁松动时（不建议消化到细胞漂浮）去掉胰_酶，加 6~8ml 培养基，轻轻吹打细胞层 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Neoantigen vaccine is a promising breakthrough ...

Figure 1. Summary of different steps of autophagy and role of WIPI proteins is illustrated. ULK1/2 and VPS34 complexes are involved in initiation and nucleation steps. The produced ...

The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins, but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and clinical ...

Alzheimer's disease treatment is still an open problem. The diversity of symptoms, the alterations in common pathophysiology, the existence of asymptomatic cases, the different types of sporadic and ...