Fas/FasL deficiency promoted cell-mediated immunity within the CNS. Fas receptor stimulation abrogated HSV-1 induced activation and inflammatory reactions in microglia from WT mice, while lack of Fas ...

Herpes simplex virus-1 (HSV-1) is a significant human pathogen. Upon infection, HSV-1 expresses its immediate early (IE) genes, and the IE transcription factor ICP4 (infectious cell protein-4) plays a ...

4 Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada 5 Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada ...

BAC: bacterial artificial chromosome; rHSV: recombinant HSV; TCR: T-cell receptor; PD1: Programmed Cell Death Protein 1; CD40L: CD40 Ligand. Although promising, there are still some limitations to our ...

The Centers for Disease Control and Prevention (CDC) estimates that about 45 million people in the United States have genital HSV, with up to a half-million new cases identified each year.

We demonstrate here that cell surface expression of HSPG alone is insufficient for AAV infection, and that AAV also requires human fibroblast growth factor receptor 1 (FGFR1) as a co-receptor for ...

Ryan Alto, 48, a father-of-two has been left battling seizures and hallucinations after a regular trip to the ER revealed he ...

[25] PCR has shown that HSV-2, [26] and less often HSV-1, [27] causes benign recurrent lymphocytic meningitis, which is usually self-limited. HSV-2 encephalitis occurs most often in newborn babies ...

Genital herpes is a sexually transmitted infection (STI) that causes painful fluid-filled bumps to form in the genital area. It is incredibly common, and roughly 12.1% of the United States population ...

Glucagon-like peptide 1 receptor agonist use was not associated with an increased risk for thyroid cancer compared with use of dipeptidyl peptidase-4 inhibitors. HealthDay News — Glucagon-like peptide ...

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Kidney stones are among the possible risks of GLP-1 use that were not previously known. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) may have a wider range of benefits and risks than what ...