The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

研究人员解析 HIV-1 包膜糖蛋白三聚体结构，揭示 MPER 作用及 Env 构象调控机制，助力抗 HIV 研究。 研究背景：HIV 研究中的关键谜题 人类免疫缺陷病毒（HIV-1）如同一个隐藏在黑暗中的杀手，悄无声息地破坏着人体的免疫系统，引发获得性免疫缺陷综合征（AIDS）。

Computational analysis of the variations in the HIV-1 genome sequence that correlate with preferential binding to the CCR5 (C-C-motif receptor 5) or CXCR4 (C-X-C motif receptor 4) coreceptors in ...

T140 Kyoto University Preclinical HIV, cancer metastasis, leukemia, rheumatoid arthritis A downsized analog of T22 peptide that specifically inhibits CXCR4 KRH-3955 Kureha Preclinical HIV ...

But will inhibitors aimed at the CCR5 co-receptor force HIV-1 to evolve more virulent forms? Other targets for entry inhibitors include two co-receptors on the cell surface—CCR5 and CXCR4 ...

This image shows CCR5 side-by-side with alternate HIV co-receptor CXCR4. While the two share similar overall architecture, their binding pockets show important differences in shape and charge ...

STAGED INVASION: Understanding the role of coreceptors CCR5 and CXCR4 provides a clearer picture of AIDS disease progression, says NIAID's Edward Berger. TAKING AIM: Chemokine receptors provided a ...