Many peptide medications like glucagon-like peptide-1 (GLP-1) receptor agonists were initially developed to treat type 2 diabetes. One unexpected side effect of these drugs is weight loss.

Intranasal vaccination is a desired route for protection against influenza viruses by mucosal and systemic immunity. However, the nasal mucosa impedes the intranasal delivery of vaccines. Here, we ...

Each chain is initially synthesized as a precursor polypeptide, which is then cleaved into two parts: HA1 (328 amino acids) and HA2 (221 amino acids), connected by disulfide bonds. 5 In this study ...

They may also be signalling molecules that act through interaction with specific receptors, as in peptide hormones and cytokines. Recently developed chemical and enzymatic methods to cyclize ...

(D) Bar graphs showing the percentage cleavage efficiency for each trimming step for mutant enzyme compared to WT enzyme. Cleavage events where the precursor Aβ peptide level was zero (i.e., no ...

The impacts of highly pathogenic enveloped viruses, such as SARS-CoV-2, have turned scientific inquiry toward the fusion mechanisms responsible for viral pathogenesis and to seek cost-effective and ...

Peptide lip treatments are super popular right now. A trend led by Hailey Bieber, who launched her now-cult Rhode Lip Peptide Treatment in 2022, the category has since grown and brands have been busy ...

RRRQRRKKRGGDIMGEWGNEIFGAIAGFLG是一种名为TAT-HA2 Fusion Peptide的多肽序列‌。TAT-HA2 Fusion Peptide是一种基于肽的递送剂，结合了来自Influenza的pH敏感HA2融合肽和来自HIV的细胞穿透肽TAT。这种多肽具有独特的细胞穿透能力和内体释放特性，使其在生物医学研究中具有广泛应用‌ ...

The most effective FOXM1-interfering peptide (FIP) was FIP4, which contained phosphorylated Ser376. FIP4 inhibited FOXM1 phase separation and transcriptional activity in cancer cells, and ...

The antigens consist of M2 ion channel’s extracellular domain (M2e), the conserved epitope of located in HA2 of hemagglutinin (H1, H3, B), and HA1 of hemagglutinin. At the same time, trimeric ...

We herein developed a repository of plant peptides predicted to have multiple therapeutic functions, named as MFPPDB (multi-functional plant peptide database). MFPPDB including 1,482,409 single or ...

Meiotic chromosomes are highly compacted yet remain transcriptionally active. To understand how chromosome folding accommodates transcription, we investigated the assembly of the axial element, the ...