Off-label uses outside of the drug's formal Food and Drug Administration (FDA) approval can include migraines and other health issues. Researchers continue to investigate ACE inhibitor use in treating ...

Currently, three GPIIb/IIIa antagonists are available: abciximab, eptifibatide and tirofiban. Abciximab is a noncompetitive irreversible inhibitor of GPIIb/IIIa. It is the humanized chimeric Fab ...

The five-year stage 3 breast cancer survival rate is 86.3%. This means roughly 86.3% of those with stage 3 breast cancer will still be alive five years after diagnosis. Cancer survival depends on many ...

retroperitoneal bleeding 54 REPLACE-2 PCI-elective Bivalirudin + provisional GPIIb/IIIa inhibitor vs heparin + planned GPIIb/IIIa inhibitor REPLACE-2 ‘major bleeding’, intracranial ...

Abdominal aortic aneurysm (AAA) is a localized expansion of the abdominal aorta which can lead to lethal complication as the rupture of aortic wall. Currently there is still neither competent method ...

Thrombocytopaenia with platelets <50×10 9 /L. Any prior intracranial haemorrhage. Use of glycoprotein IIb/IIIa inhibitor during percutaneous coronary intervention. Administration of thrombolytic ...

Furthermore, drug-dependent antibodies can also target platelets, resulting in thrombocytopenia (11). The binding sites of drug-dependent antibodies can be localized to GPIIb/IIIa and GPIb/IX in ...

Integrins require an activation step prior to ligand binding and signaling. How talin and kindlin contribute to these events in non-hematopoietic cells is poorly understood. Here we report that ...