The replication fork is more than just a means for DNA duplication. It is connected to a checkpoint system that keeps the genome intact and prevents cancer. Aa Aa Aa Eukaryotic genomes are ...

Figure 1: Mechanism of DNA replication in eukaryotes. A large multi-subunit protein complex, called replisome, coordinates DNA unwinding with DNA synthesis at the fork. Over 20 distinct proteins and ...

and it has recently been shown that eukaryotic chromosomes are also highly catenated along their lengths. We expect that our work will lead to a better understanding of the factors that limit ...