Figure 3. Ferroptosis sensitivity of HER2 positive breast cancer with different trastuzumab response. (A-B) Knockdown of SLC7A11 (A) and GPX4 (B) induced increased lipid peroxidation (BODIPY-C11) in ...

Ferroptosis sensitivity of HER2 positive breast cancer with different trastuzumab response. (A-B) Knockdown of SLC7A11 (A) and GPX4 (B) induced increased lipid peroxidation (BODIPY-C11) in JIMT1. (C-D ...

诱导 PDAC 细胞铁死亡可降低由 ACOT8 高表达引起的吉西他滨耐药性 ：研究人员将吉西他滨与铁死亡诱导剂 erastin 联合处理细胞， 实验显示联合处理显著降低了细胞对吉西他滨的耐药性，ACOT8 表达的细胞和类器官模型的生长也受到明显抑制。这表明 ACOT8 的抗铁死亡作用是导致吉西他滨耐药的关键因素。

Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ...

Erastin, lapatinib, ferrostatin-1 (Fer-1), liproxstatin-1 (Lip-1 ... Cells were washed twice with PBS, trypsinized, and then incubated with 500 μl HBSS (C14175500BT, Gibco, United States) supplemented ...

Department of Pharmacology, Korea University College of Medicine, Korea University, Seoul 02841, South Korea ...

Zhejiang Key Laboratory of Imaging and Interventional Medicine, Zhejiang Engineering Research Center of Interventional Medicine Engineering and Biotechnology, The Fifth Affiliated Hospital of Wenzhou ...