In addition, an induced fit basis for substrate specificity of enzymes was rationalized from simple physical principles of enzyme kinetics. Of particular note is the proposal that ‘entropic guidance’ ...

"Using these detailed ensembles of enzyme states, we've been able to quantify and rigorously explain in chemical detail what features in enzymes provide catalysis and by how much," said the study ...

The mechanism of enzyme catalysis is similar in principle to other types of chemical catalysis, for instance by involving a combination of several different types of catalysis. Determining enzyme ...

Synthetic proteins that promote multi-step catalysis have previously proven challenging to engineer. But the team behind this ...

This illustration depicts the process of enzyme catalysis. The enzyme (blue) binds to its substrate (red) to form an enzyme-substrate complex. The enzyme then catalyzes the conversion of the substrate ...

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells ...