In addition, an induced fit basis for substrate specificity of enzymes was rationalized from simple physical principles of enzyme kinetics. Of particular note is the proposal that ‘entropic guidance’ ...

The mechanism of enzyme catalysis is similar in principle to other types of chemical catalysis, for instance by involving a combination of several different types of catalysis. Determining enzyme ...

"Using these detailed ensembles of enzyme states, we've been able to quantify and rigorously explain in chemical detail what features in enzymes provide catalysis and by how much," said the study ...

Enzymes are biological catalysts that lower the activation energy of chemical reactions, allowing them to proceed at a faster rate. This illustration depicts the process of enzyme catalysis. The ...

Synthetic proteins that promote multi-step catalysis have previously proven challenging to engineer. But the team behind this ...

Stanford researchers have illuminated how enzymes are able speed up life-sustaining biochemical reactions so dramatically. Their discoveries could impact fields ranging from basic science to drug ...

Cancer cells have an insatiable appetite for energy as they multiply more rapidly than normal cells. Greedy cancer cells ...