The rise of antibiotic resistance demands urgent research into its molecular mechanisms to inform the development of ...

Journal of Nuclear Medicine February 2025, jnumed.124.269322; DOI: https://doi.org/10.2967/jnumed.124.269322 Efflux transporters of the adenosine triphosphate ...

Work by Brosseau et. al. combines NMR, biochemical assays, and MD simulations to characterize the influence of the C-terminal tail of EmrE, a model multi-drug efflux pump, on proton leak. The authors ...

United States The model multi-drug efflux pump from Escherichia coli, EmrE, can perform multiple types of transport leading to different biological outcomes, conferring resistance to some drug ...

UK Health Security Agency, Research and Development Institute, National Infection Service, Porton Down, Salisbury, Wiltshire SP4 0JG, U.K. Institute of Pharmaceutical Science, School of Cancer & ...

State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, People’s Republic of China ...

Researchers from Okayama University of Science have identified bitter taste receptors in keratinocytes (skin cells).

Cancer therapy has advanced with molecularly targeted approaches and immunotherapy, yet chemotherapy remains essential for ...

Stomata, microscopic pores on plant leaves, regulate gas exchange and water loss by opening or closing in response to ...

Researchers from Okayama University of Science have made a groundbreaking discovery, identifying bitter taste receptors in ...

Secretion of IL-1β required a cytokine maturation process which depends on the NLRP3 inflammasome activation. This intracellular multiprotein complex can be stimulated by ATP-dependent potassium (K +) ...

Hepatic steatosis, often triggered by non-alcoholic fatty liver disease (NAFLD), is a leading cause of liver dysfunction ...