EGFR was the first ERBB receptor whose internalization mechanisms ... routing to another area of the cell, degradation, and any combination thereof, and they vary greatly between different ERBB ...

have now designed autophagy-inducing antibodies (AUTABs) that promote internalization and lysosomal degradation of their target cell surface receptor ... such as EGFR (by linking PEI to the ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

The phosphorylation of protein kinases leads to the activation of signal-transduction pathways, which have a critical role in a variety of biologic processes, including cell growth ...