Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...

To this end, recent clinical and preclinical studies have implicated the epidermal growth factor receptor signaling pathway in chronic pain states. EGFR is one of four members of the ErbB family of ...

The phosphorylation of protein kinases leads to the activation of signal-transduction pathways, which have a critical role in a variety of biologic processes, including cell growth ...

present fundamental data with new insights into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling mediators ... have ...

present fundamental data with new insights into the role of Ezrin, a major membrane-actin linker that assembles signaling complexes, in the spatial regulation of EGF signaling mediators ... have ...

Etern Biopharma (Shanghai) Co. Ltd. has identified proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase binding moiety coupled to an androgen receptor targeting moiety through a ...

Trastuzumab has been proposed to trigger HER2 internalization and degradation through promoting the activity of tyrosine kinase ... CDK2, cyclin-dependent kinase 2; EGFR, epidermal growth factor ...

Shanghai Yidi Biotechnology Co. Ltd. has synthesized proteolysis targeting chimeras (PROTACs) comprising an E3 ubiquitin ligase coupled to an androgen receptor targeting moiety via a linker reported ...