Here we report an activity-dependent stabilization of the MAP kinase (MAPK) pathway, prominent in hippocampal dendrites. The longevity of the signal in these dendrites was increased to hours when ...

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The Israelites were near their last encampment and would soon cross the Jordan River to enter into the promised land. Some of them had been children when, with their parents, they had left Egypt; ...

Continued strong commercial execution of the OGSIVEO launch in the U.S. with fourth quarter and full-year 2024 U.S. net product revenue for OGSIVEO of $61.5 million and $172.0 million, respectively.

结果发现，rhREG3A 处理后，细胞中与 EGFR - MAPK 信号通路相关的基因上调。磷酸激酶阵列和蛋白质免疫印迹分析显示，rhREG3A 能激活 MAPK 促增殖通路，使 EGFR 和 ERK 磷酸化，还能诱导 EGFR 二聚化。共免疫沉淀和双免疫荧光染色发现，REG3A 和 EGFR 在细胞内共定位 ...

Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to find out the biological function and related signal pathways. The expressions of amphiregulin, epiregulin and ...

SS 通过直接结合 ERK2 或表皮生长因子受体（EGFR）调节 ERK2/MAPK 通路的活性 研究人员预测了 ERK2 和 EGFR 的磷酸化位点，通过分子对接发现龙葵碱可以与 ERK2 和 EGFR 结合，主要通过氢键和疏水相互作用形成稳定的复合物。这一结合可能会影响 ERK2 的 Thr185 和 EGFR 的 ...