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The Earthsavers Dreams International Theater Institute Center, in cooperation with the University of Makati’s (UMAK) Center for Culture & Arts, will be hosting the United Nations Sustainable ...

The Indian government is set to notify its new Electric Vehicle (EV) policy, which aims to lower import duties and attract global players like Tesla. The policy is expected to mandate a minimum ...

What once was a futuristic concept is now very much a reality, with dozens of companies offering services from the likes of Carbar and Carly, to eCar (East Coast Subscriptions), Karmo and Loopit ...

Surprisingly, the seashores assay in PRMT1 overexpressing cells showed no further enhancement in the ECAR after adding mitochondrial decoupler FCCP, indicating the truncated mitochondrial energetics.

免疫系统中的巨噬细胞以其吞噬和消化外来入侵者——例如细菌和病原体——的能力著称。作为身体的“清道夫”，巨噬细胞在感染发生时负责吞噬细菌，并通过一系列复杂的细胞内过程将其降解。然而，尽管我们对巨噬细胞吞噬功能的防御角色有所了解，但对被吞噬细菌的最终命运 ...

ONECUT3 是与 CRC 糖酵解相关的关键转录因子 ：研究人员分析 TCGA 数据库中结肠癌样本的 RNA 测序数据，根据糖酵解相关基因的表达水平将样本分为高糖酵解组和低糖酵解组，筛选出差异表达基因，发现 ONECUT3 是最显著的差异表达基因。通过免疫组化染色进一步证实，ONECUT3 在结直肠癌组织中的表达明显增加，暗示其可能通过糖酵解在 CRC 中发挥调控作用。

在研究结论与讨论部分，研究人员指出，Pim2 有望成为治疗炎症性关节炎的关键靶点。抑制 Pim2 不仅能够有效抑制糖酵解，还能纠正 M1/M2 巨噬细胞失衡，为炎症性关节炎的治疗开辟了新方向。贝沙罗汀作为潜在的治疗药物，虽然已在临床用于治疗皮肤 T 细胞淋巴瘤，但存在多种副作用。而 NM@NP-Bex 的出现，为解决这一问题提供了可能，它能够增强贝沙罗汀的治疗效果，同时减少全身毒性和副作用。