The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...
One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid increases in genetic technology and testing.
Mapping DNA methylomes in single cells is challenging, and thus studies using bulk samples remain common. Here, authors develop a transformer-based method for methylation pattern analysis to ...
Colorectal cancer typically is diagnosed after age 50, but in recent years the disease has been increasingly found in younger people and disproportionately affecting racial and ethnic minorities. In ...
This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...