1–3 Researchers need effective methods with high sensitivity and reliability to explore the importance of DNA methylation. The gold standard technology that scientists use to detect DNA methylation is ...

Changes in DNA methylation patterns occur early during oncogenesis, and each type of cancer has its own methylomic signature. Technological advances in methylation sequencing, or methyl-seq, allow ...

Researchers at the University of Toronto have invented a new method that uses DNA sequencing to measure metabolites. This enables rapid and precise analysis of biological compounds, such as sugars ...

A new method, "smol-seq," utilizes DNA sequencing for rapid and precise metabolite detection. It employs DNA aptamers, each with a unique barcode, to bind specific metabolites.

Unlike traditional methods, this technique does not require de novo DNA synthesis (assembling the molecule's components ... d) Parallel printing via DNMT1-guided catalysis to selectively write ...

The relationship between DNA methylation and gene expression is driven by sequence variants, according to a recent study conducted by researchers at deCODE Genetics, an Amgen subsidiary.

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

A new study shows that long-read sequencing has the potential to improve the rate of diagnosis while reducing the time to diagnosis from years to days — in a single test and at a much lower cost.

The SPRQ chemistry brings three major benefits: 4x lower DNA input, 33% higher sequencing yield and more accurate direct methylation detection. With only 500 ng of DNA needed for a human whole genome, ...