Objectives Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic burden with high unmet medical needs. Recent clinical evidence suggests ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

Profiling cells from ovarian endometriosis revealed signaling interactions that may sustain lesion growth, highlighting ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

To this end, recent clinical and preclinical studies have implicated the epidermal growth factor receptor signaling pathway ... pain and neuropathic pain. Though we have discussed how EGFR may ...

This study aimed to identify the influence of alcohol consumption and COVID-19 on pain. Using publicly available curated gene expression data sets of differentially expressed genes (DEGs) in the ...

Pain under the left armpit may result from muscle damage or swollen lymph nodes due to an infection. However, it can also indicate a more serious problem, such as cancer or angina. The armpit is a ...

Defects in control of apoptotic pathways may contribute to a variety of diseases including cancer, autoimmune and neurodegenerative conditions and AIDS. While many components of the regulatory ...

Their plasticity may hold the key to underlying mechanisms in IBS. Our aim was therefore to determine the contribution of each afferent class in each pathway towards post-inflammatory visceral ...

Importance Patellofemoral pain (PFP) is both chronic and prevalent ... about your clinical reasoning for those treatments that are not evidence based (if yes to previous question)? Reflections on ...

What Does Liver Pain Feel Like? Your liver is a football-sized organ that sits under your ribs. It filters and cleans your blood, stockpiles energy, helps you fight infections and diseases ...