Structural and cellular assays and molecular dynamics simulations reveal the mechanism of action of γ-glutamyl carboxylase, which involves cholesterol and vitamin K. Protein kinase R-like ...

Established acute therapies, such as the 'triptans'-5-HT 1B/1D receptor agonists, NSAIDs COX inhibitors and calcitonin gene ... novel targets that have mechanisms of action at both peripheral ...

Expert Rev Clin Pharmacol. 2013;6(3):271-288. Triptans are highly effective for short-term treatment of acute migraine attacks. They are effective in MA or MO, but are not intended for use in ...