Northwestern Medicine scientists have discovered that inhibiting the GATA6 protein in mouse models of colon cancer reduced ...

研究人员发现 HepG2 细胞中 BAP1 主要在细胞核表达，于是他们通过实验敲低了 HepG2 细胞中的 BAP1 蛋白表达。神奇的事情发生了，原本 “安分守己” 的癌细胞变得异常活跃，细胞迁移能力显著增强，就像被解开了束缚的 “小怪兽”。而在主要表达细胞质 BAP1 的 PLC/PRF/5 和 Huh7 细胞中，敲低 BAP1 并没有对细胞迁移能力产生明显影响。

为解决传统 DNA 甲基化检测技术的局限，英国巴斯大学研究人员开展 5mC 和 5hmC 纳米孔测序研究。结果显示该技术检测准确，还能研究修饰对称性。这为相关领域提供新方法，极具科研价值，推荐大家阅读。

The manuscript addresses the 3D chromatin architecture in monocytes from patients with alcohol-associated hepatitis and its relationship to enhanced transcription of innate immune genes. While the ...

We identified increased chromatin accessibility, transcription factor binding including CTCF-mediated insulation, differential occupancy of H3K36me3 and H3K79me2, and changes in transcriptional ...

Here we report the first genome-wide survey of regulatory elements in any sheep immune cell, utilizing alveolar macrophages. We assayed histone modifications and CTCF enrichment by chromatin ...