Golgi Plug (1/1000 final dilution) was added during the last 10 h of culture together with anti-CD107a antibody (BV421, clone H4A3). During the VIA coculture, prestimulated CD8+ T cells with infected ...

Background: In people living with HIV (PLHIV), the CD4/CD8 ratio has been proposed as a useful marker for non-AIDS events. However, its predictive ability on mortality over CD4 counts, and the role of ...

为探究 HIV-1 基因组中 ARF 的情况，巴黎萨克雷大学等机构研究人员开展相关研究。他们发现 98 个 ARF，部分编码多肽引发 T 细胞反应。该成果为 HIV 疫苗设计提供新靶点，强烈推荐科研读者阅读。

且肿瘤浸润的CD8+ T细胞在总活细胞中的比例上升，特别是IFN-γ、颗粒酶B和CD107a的细胞比例。总体而言，去除pTreg细胞对荷瘤小鼠产生了有效的治疗效果。 肿瘤内Treg细胞高度表达T-bet转录因子 接着，该研究分析了肿瘤内Treg细胞是否在基因表达上与任何Th亚群相似 ...

Antigen-specific CD8+ T cells are recruited and then respond to foreign antigens, expand, eliminate infected cells, and produce interferon-γ, which stimulates innate immune cells and increases ...

1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...

In a new study published in Nature, led by scientists at the Allen Institute, La Jolla Institute for Immunology, and UC San Diego, researchers reveal how cells known as tissue-resident memory CD8 ...

为解决 HIV 无法治愈难题，西班牙巴塞罗那瓦尔德希伯伦大学医院等单位研究人员开展 Bi-Ab32/16 抗体研究。结果显示其体外有效，体内却导致 NK 细胞减少影响病毒控制。该研究为 HIV 免疫疗法提供关键线索，强烈推荐科研人员阅读。

Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM.

This study on mouse Ly49 receptors expressed on natural killer (NK) cells shows that Ly49A, in the presence of the corresponding MHC Class I allele, can lead to NK cell licensing, thereby providing ...

Objective Elucidating complex ecosystems and molecular features of gallbladder cancer (GBC) and benign gallbladder diseases is pivotal to proactive cancer prevention and optimal therapeutic ...