为探究非强化治疗急性髓系白血病（AML）患者的预后因素，阿姆斯特丹大学医学中心的研究人员开展研究，发现 CD34 + CD38-白血病干细胞（LSC）状态与患者预后显著相关，为治疗决策提供参考。 一、研究背景 在血液疾病的治疗领域，急性髓系白血病（AML ...

“Gene therapy for hemophilia A with the use of lentiviral vector-transduced autologous HSCs resulted in stable factor VIII expression, with factor VIII activity correlating to vector copy number in ...

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在新冠疫情这场全球性的风暴中，新冠病毒（SARS-CoV-2）的身影无处不在，它给人类健康和社会发展带来了沉重打击。SARS-CoV-2 主要侵袭呼吸系统，可很多患者在感染后，不仅呼吸出现问题，血液指标也变得异常，像是贫血、淋巴细胞减少和血小板减少等情况屡见不鲜。此前研究虽发现 SARS-CoV-2 ...

Early results from the company’s single-arm trial saw the therapy able to partially repair the chemical responsible for ...

本产品可以通过阴性分选法从人细胞样品中富集CD34+细胞。原理是利用生物素（biotin）标记的单克隆抗体对非目标细胞（非CD34+细胞）进行标记，然后通过链霉亲和素（streptavidin）标记的磁珠对非目标细胞进行清除，从而达到富集CD34+细胞的目的。分选过程需要用 ...

Based on early Phase I/II data, investigators at Cincinnati Children's are enrolling more patients with a telomere biology ...

Donor selection in T-cell-replete haploidentical donor peripheral blood stem cell transplantation. Leukemia. 2025;1-11.

The Food and Drug Administration (FDA) has granted Orphan Drug designation to EXG-34217 for the treatment of telomere biology disorders.

它由Vertex Pharmaceuticals和CRISPR Therapeutics开发。 Exagamglogene autotemcel 4–13×10^6 CD34+ 细胞/kg体重；每瓶；用于静脉输注的细胞悬浮液；含有 5% 二甲基亚砜 (DMSO)、葡聚糖 40。 输注后，编辑后的CD34 +细胞植入骨髓并分化为 BCL11A 表达降低的红系细胞。BCL11A 表达降低导致 ...

Discover how hyperbaric oxygen therapy influences telomeres, stem cells, and mitochondria. New research reveals promising ...