BioLegend), anti-CD19 APC (clone HIB19, BD Pharmigen), anti-CD25 APC (clone 2A3, BD Pharmigen), anti-CD71 FITC (clone CY1G4, BioLegend), anti-Myc FITC or APC (clone 9B11, Cell Signaling, Danvers, MA), ...
MYC is a pleiotropic transcription factor involved in multiple cellular processes. While its mechanism of action and targets are not completely elucidated, it has a fundamental role in cellular ...
4 Institute of Pathology and Comprehensive Cancer Center EMN, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany Objectives CD19-targeting chimeric ...
Galapagos is dropping its junior CD19 CAR-T as part of the Belgian biotech’s seemingly never-ending mission to recalibrate the business. The company had been planned to secure permission from ...
目前, 河南省肿瘤医院血液科淋巴瘤病区 有9项淋巴瘤临床研究正在进行,有需要的患者朋友欢迎电话咨询详情。 一项研究 “抗CD19/CD20嵌合抗原受体自体T细胞注射液(C-CAR039)治疗CD19或CD20阳性的复发或难治性大B细胞淋巴瘤的Ib/II期临床研究” (CTR编号 CTR20222827)。该研究已经通过医院伦理委员会的审查(CTMS编号 2023-477)。
目前,河南省肿瘤医院血液科淋巴瘤病区有9项淋巴瘤临床研究正在进行,有需要的患者朋友欢迎电话咨询详情。01一项研究“抗CD19/CD20嵌合抗原受体自体T细胞注射液(C-CAR039)治疗CD19或CD20阳性的复发或难治性大B细胞淋巴瘤的Ib/II期临床研究”(CTR编号 CTR20222827)。该研究已经通过我院伦理委员会的审查(CTMS编号 ...
慢性淋巴细胞白血病(CLL)患者中,约10%会经历一种致命转变——转化为侵袭性更强的弥漫大B细胞淋巴瘤(DLBCL),这一过程被称为“Richter转化”(RT-DLBCL)。尽管此类患者的中位生存期不足1年,但关于其生物学特征的研究长期匮乏。202 ...
Here, we review the ongoing developments with CAR T cells in the field of autoimmune disorders. We will cover first clinical results of applying anti-CD19 and anti-B cell maturation antigen CAR T ...
将 MYC 和 BCL-2 条件性敲入小鼠与 CD19-Cre 小鼠杂交,以实现 B 细胞谱系中 MYC 和 BCL-2 的特异性过表达。通过蛋白质印迹法证实了 MYC 和 BCL-2 的过表达。
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case ...