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16 小时
Fgf14 基因敲除赋予小鼠抗抑郁和抗焦虑能力:潜在的抑郁症治疗新靶点
Fgf14-/-小鼠对抑郁样行为具有抵抗作用 :在 TST 中,Fgf14 -/- 小鼠的不动时间显著减少,首次不动的潜伏期延长,这表明它们表现出较低水平的绝望行为;在蔗糖偏好测试中,Fgf14 -/- 小鼠对蔗糖溶液的消耗明显增加,说明其感受快乐的能力更强;在三室社交测试中,Fgf14 -/- 小鼠与陌生小鼠的互动增多,与无生命物体的互动减少,显示出更高的社交能力。
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