The blood-brain barrier has confounded the development ... charge and lipid solubility of a compound to facilitate BBB transport. The apical sides of endothelial cells, which face the blood ...

The blood–brain barrier is the biggest challenge to the development of drugs that target the CNS. Most capillary beds leak plasma contents between and across endothelial cells by way of window-like ...

Financial writer recommends Voyager Therapeutics, Inc. for high-risk investors due to promising preclinical Alzheimer's ...

is a passive impermeable barrier that segregates blood and brain interstitial fluid has given way to the concept that the BBB is a dynamic conduit for transport between the blood and the brain for ...

The paper is titled "Intravenous administration of blood-brain barrier-crossing conjugates facilitate biomacromolecule transport into central nervous system." The blood-brain barrier is a natural ...

The BCC10 compound uses transcytosis to prompt cells in the blood-brain barrier to transport the drugs across the barrier from within, researchers said. The treatment was well-tolerated in the ...

The blood-brain barrier (BBB) is a cellular fortress that regulates what comes in and goes out of the brain. It ensures that the brain has access to key nutrients while protecting it from pathogens ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

A paper published Monday in Nature Medicine found that the tiny fragments of plastic are passing the blood-brain barrier and into human brains, and the amount of microplastics in the brain appears ...

Rice University chemist and director of the university’s Synthesis X Center Han Xiao and cancer biologist Dihua Yu of The ...