Recent research has focused on understanding the complex biosynthetic pathways and regulatory mechanisms that govern the production of these valuable metabolites, providing insights that could ...

The biosynthesis of cysteine occurs through a two-step enzymatic pathway involving serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). Recent research has focused on ...

Proteins created by cells often are not used by the cell that synthesised them. These proteins go through the protein secretory pathway and are, as the name suggests, secreted out of the cell. This ...

Nonetheless, this dynamic organelle – located at the intersection of the secretory and endocytic pathways and characterized by its unique organization into ... as well as the sorting of these newly ...

Department of Chemistry, University of Alberta, Edmonton T6G 2R3, Canada ...

However, PC is a “cold tumor” with a unique immunosuppressive tumor microenvironment (poor effector T cell infiltration, low antigen specificity), and targeting a single gene or pathway is basically ...

This study presents a valuable finding on the role of secretory leukocyte protease inhibitors (SLPI) in developing Lyme disease in mice infected with Borrelia burgdorferi. The evidence supporting the ...

This fundamental work presents two clinically relevant BMP4 mutations that contribute to vertebrate development. The convincing evidence supports that the site-specific cleavage at the BMP4 pro-domain ...

Hope is not passive wishing but an active, dynamic process. According to Hope Theory, hope involves two components: agency and pathways. Agency is the belief in one’s capability to act ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

MOE Key Laboratory of Bio-Intelligent Manufacturing, State Key Laboratory of Fine Chemicals, Frontiers Science Centre for Smart Materials Oriented Chemical Engineering, School of Bioengineering, ...