A key discovery was the activation of the HIF1α-HMOX1 axis, which drives excessive autophagy and ferritin degradation, leading to intracellular iron overload and lipid peroxidation, hallmarks of ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...

However, its role in melanoma tumor growth remains insufficiently explored. This study investigates the inductive effect of itraconazole on autophagy-mediated apoptosis in melanoma cells. Method: ...

In our research we looked at the functional composition of forests, and disentangled the causal effects of forest loss, fragmentation and local degradation, three interrelated processes in human ...

1Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul, Republic of Korea. 2Department of Biomedical Sciences, College of Medicine, Seoul National University, ...

As the hunt for effective cancer therapies intensifies, some scientists are turning back to look at old drugs in a new light. The anti-malarial hydroxychloroquine is one such drug that has been ...

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...

These results suggest that, in the recruitment of K63 and K27 ubiquitin chains to PDE9A, CHIP triggers its sequential ubiquitination and subsequent degradation via the autophagy–lysosomal pathway.

Abstract: In converter applications, the body diode SiC MOSFET is often repurposed as freewheeling diode to reduce cost and save space, it potentially leads the device to bipolar degradation. This ...