The term 'autophagy' was chosen to distinguish the lysosomal degradation, or 'eating' (phagy), of part of the cell's self (auto) from the breakdown of extracellular material (heterophagy).

They were also able to artificially create these conditions and thus trigger the degradation of otherwise non-degradable molecules in yeast cells. Targeting autophagy in this way is a promising ...

Intracellular constituents such as proteins and organelles are turned over by unremitting synthesis and degradation. This dynamic turnover is critical for homeostasis, development, and environmental ...

Autophagy targets a range of intracellular components, including a part of the nucleus that stores important chromosomes. However, the physiological significance of autophagic degradation of the ...

They were also able to artificially create these conditions and thus trigger the degradation of otherwise non-degradable molecules in yeast cells. Targeting autophagy in this way is a promising ...

Autophagy not only provides a nutrient source through intracellular degradation but also plays a crucial role in maintaining ...

Florian Wilfling from the Max Planck Institute of Biophysics in Frankfurt has now discovered the conditions necessary for autophagy to start. They were also able to artificially create these ...

This process, known as autophagy, is like a self-cleaning mechanism for cells, ... Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently altered in diseases, including neurodegenerative disease. To this end ...

In a recent study published in the journal Neuron, researchers at the University of Cambridge and Newcastle University, UK, examined the relationship between autophagy, aging, and neurodegeneration.

Get Instant Summarized Text (Gist) Autophagy, particularly through the protein ATG5, plays a crucial role in maintaining brain health by regulating glucose metabolism in neurons. In Purkinje cells ...