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重磅发现!普通肝素经 Ang/Tie2 通路 “击退” 组蛋白引发的肺损伤 ...
Ang - 1 就像一个 “守护者”,作为 Tie2 的激动剂,它能磷酸化 Tie2,激活 Akt 并抑制 FOXO1,从而促进内皮细胞稳定。而 Ang - 2 则像是 “捣乱者”,作为 Tie2 的拮抗剂,它会对抗 Ang - 1 的稳定作用。研究发现,Ang - 2 是脓毒症中凝血、炎症反应和内皮功能障碍的核心 ...
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