Given that extracellular ATP through P2X7 receptor constitutes a neuron-to-microglia alarm signal implicated in ALS, and that P2X7 affects autophagy in immune cells, we have investigated if autophagy ...

Both models did show significantly elevated TSPO binding in the affected brain regions. Since P2X7 is activated by micro- to millimolar levels of ATP (normal ∼ nanomolar range), it is plausible that ...

umin.ac.jp Objective Extracellular ATP mediates mast cell-dependent intestinal inflammation via P2X7 purinoceptors. We have previously shown that CD300f (also called the leucocyte ...

Secretion of IL-1β required a cytokine maturation process which depends on the NLRP3 inflammasome activation ... Interestingly, K + efflux, associated with ATP release, could be the initial signal of ...