To explore one of the leading causes of cancer-related deaths, researchers from three institutes conducted a study by collecting stomach lining samples.

在这项研究中，作者对来自30名志愿者（包括18名胃癌患者和12名健康个体）的238个胃腺体进行了全基因组测序。胃腺体是胃上皮的基本单位，每个腺体通常由一个干细胞的后代细胞组成，会形成单克隆细胞群。他们发现正常胃腺体细胞每年大约会积累27.8个单核苷酸 ...

Impact of Insurance Status on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma This retrospective analysis included patients with cancer who had commercial ctDNA tests (K-Track, Gene ...

The Selective ARID1B degrader program targets ARID1B in ARID1A-mutated cancers, addressing a synthetic lethal target in solid tumors. Disclaimer: This is an AI-generated summary of a press release ...

Selective degradation of ARID1B achieved. Earlier this year, Foghorn announced that the company has achieved selective degradation of ARID1B and will provide a program update during 2025.

1 Department of Pathology, Affiliated Hospital of Guilin Medical University, Guilin, China 2 Department of Pathology, Guanyang County People’s Hospital, Guilin, China Dedifferentiated endometrial ...

Racing to stem a surge in early-onset colorectal cancer: After identifying a growing wave of early-onset colorectal cancer cases, researchers are hoping to investigate potential culprits and ramp ...

Condition: Advanced Solid Tumor, Diffuse Large B Cell Lymphoma, Lymphoma, T-Cell, Mesothelioma, Malignant, Prostatic Neoplasms, Castration-Resistant, Endometrial ...

分析突变景观：研究人员绘制了 121 个先前定义的膀胱癌相关基因的常见体细胞突变高分辨率图谱。其中，TP53 是突变频率最高的基因，之后依次是 KMT2D、ARID1A 等。不过，虽然 FGFR3 突变通常与免疫浸润减少有关，但研究发现它与 ICI 治疗反应并无关联。唯一与 ...

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