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优化与预测 Cre 重组酶:开启小鼠精准基因组编辑新篇章
为解决 Cre-Lox 系统在小鼠基因编辑中存在的成本高、时间长、重组不可预测等问题,研究人员开展了对 Cre 介导重组的系统分析研究。结果发现多种因素影响重组效率,如 lox P 距离等。该研究为优化 Cre 介导重组提供框架,提高实验精度,降低成本。
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