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生物谷
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中国学者一作Cell论文:绕过血脑屏障,利用细菌从鼻腔向大脑递送药物
研究团队进一步改造出了能够分泌三种调节食欲的激素的 Lp 基因工程菌,在饮食诱导的肥胖小鼠模型中,该基因工程菌经鼻腔给药后,显著减轻了肥胖相关症状,肥胖小鼠表现出食欲下降、体重增加减少、葡萄糖代谢改善和脂肪沉积减少。这些结果证明了 Lp ...
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