In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove large ...

Within 7SK snRNP, Tat may replace HEXIM1 from the 7SK 5′-hairpin structure and P-TEFb via its ARM and activation domain, respectively, and thus remove it from its preferred position.