Structure-based drug design is the design and optimization of a chemical structure with the goal of identifying a compound suitable for clinical testing — a drug candidate. It is based on ...

Its long-separated twin—the minor spliceosome, is much more scarce and remains enigmatic, even though its function is equally important. In this study, the researchers reveal the structure of U11 ...

In this new study, the researchers reveal the structure of U11 snRNP – one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells ...

In this study, the researchers reveal the structure of U11 snRNP—one of the five subunits of the minor spliceosome, which initiates the intron selection process. Spliceosomes help cells remove ...

Astronomers have discovered what may be the largest-scale structure in the known universe — a group of galaxy clusters and clusters of galaxy clusters that spans roughly 1.3 billion light-years ...

The crystal structure of pseudouridine synthase I from Escherichia coli, which, for example, modifies positions 38, 39 and/or 40 in tRNA, reveals a dimeric protein that contains two positively ...

As the most abundant internal modification in eukaryotic cells, N6-methyladenosine (m6A) in mRNA has shown widespread regulatory roles in a variety of physiological processes and disease progressions.

Conclusions Our algorithm showed robust performance in predicting visual impairment in patients with RP, thus providing proof-of-concept for predicting structure-function correlation based solely on ...

YT and H-MJ wrote the draft of the manuscript. ZY and Y-SH collected the data. R-SZ contributed to the discussion. D-YZ and H-FP organized the structure of the manuscript. YT and D-YZ contributed to ...

E complex is the earliest spliceosome precursor in which the 5' SS and BS are defined. Definition occurs by U1 small nuclear ribonucleoprotein (snRNP) binding the 5' SS and recognition of the BS by ...

For the experiments, gamma-secretase was exposed to an inhibitor molecule that stopped it from cutting other proteins. This meant that the structure of gamma-secretase became more rigid than normal, ...