Upon fatty acid activation, UCP1 facilitates proton leakage, dissipating the mitochondrial proton motive force to release energy as heat. Purine nucleotides are considered to be the only inhibitors of ...

Eggs stand out as an excellent low-purine food. Purines are chemicals found in certain foods and drinks that can lead to high ...

Having gout or being at risk for the disease may mean avoiding a lot of popular foods. But how does eating eggs every day ...

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High uric acid levels can lead to gout and joint pain, but incorporating certain dry fruits into your diet can help regulate ...

While daily dietary measures and medications help reduce uric acid and manage gout symptoms, it is important to take care of ...

How is the eLife Model driving change in research? We explore some key milestones and accomplishments of the first two years ...

Uric acid is produced when purines, found in many foods, are broken down. Typically, it dissolves in the blood and is removed ...

Understanding gout Gout is a crystal arthropathy – a group of joint disorders that occur when crystals build up in joints and ...

Gout is a disease characterized by recurrent attacks of arthritis, in which uric acid appears in excessive amounts in the ...

Here, the authors link ACSS2-generated local acetyl-CoA to purine metabolism through PAICS acetylation that contributes to CCF-SASP.