Almost two decades have passed since Stanley Prusiner proposed that the transmissible agent causing spongiform encephalopathies consists of a misfolded protein — but the biology of prion ...

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60%. There is currently no cure for ...

Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

The new gene therapy aims to address the root cause of prion disease by using the CHARM epigenetic editing platform from the Whitehead Institute to target and silence the gene that codes for the ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

Protein aggregation is typical of neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team headed by Professor Jörg Tatzelt ...

Prion diseases are rare, fatal brain disorders in humans and animals caused by the accumulation of an abnormal protein (PrPSc) that leads to brain degeneration and neurological decline.

Researchers at Ruhr University Bochum discovered that a lipid anchor on nerve cell membranes stabilizes prion protein folding, preventing harmful aggregation linked to prion diseases. Their in vitro ...

Some rare forms of dementia, including Creutzfeldt-Jakob disease (CJD) are caused by a type of protein called a prion. In these conditions, the prions misfold into a toxic form and then spread ...

The center is supported by the CDC and sponsored by the American Association of Neuropathologists. The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in ...

Jan. 6, 2025 — Protein aggregation is typical of various neurodegenerative diseases such as Alzheimer's, Parkinson's and prion diseases such as Creutzfeld-Jakob disease. A research team has now ...