Our brain's remarkable ability to form and store memories has long fascinated scientists, yet most of the microscopic mechanisms behind memory and learning processes remain a mystery.

Second, the synapses that mediate these connections can be functionally very different, even when they belong to the same axon and contact the same postsynaptic target. What is the basis for this ...

By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

Computational models show that even subtle modifications in the synaptic protein CaMKII completely alter the resulting protein structures. Given how the formation and stability of these structures ...

Postsynaptic changes in AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs) are thought to be important for the expression of LTP. This could involve either the ...

Insilico Medicine Ltd. has identified postsynaptic density-95 (PSD-95) protein inhibitors acting as neuroprotective agents reported to be useful for the treatment of epilepsy, anxiety disorders, ...

This results in enough neurotransmitter being diffused across the synaptic cleft to trigger the impulse in the postsynaptic neuron. This process is called summation.

Between impulses the transmitter molecules are rapidly removed from the synaptic cleft to prevent continuous stimulation of postsynaptic neurons. There are two types of removal: Re-uptake – the ...