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PAR 代谢在哺乳动物细胞应对紫外线辐射及液 - 液相分离中的关键作用
研究聚焦紫外线辐射(UVR)对哺乳动物细胞影响,发现 PAR 代谢参与液 - 液相分离(LLPS),意义重大。 聚(ADP - 核糖)聚合酶(PARPs)主要通过翻译后修饰消耗 NAD + 来合成聚(ADP - 核糖)(PAR)。PAR 主要由聚(ADP - 核糖)糖水解酶(PARG)降解。PAR 可以是线性或 ...
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