在这项研究中，研究人员通过饮食诱导的肥胖和前驱糖尿病小鼠模型，发现巨噬细胞在周围神经病变中起着神经保护作用。巨噬细胞在疾病早期就浸润到完整的周围神经中，其表达谱与神经退行性疾病相关的髓样细胞相似，并且通过 Gal - 3 延缓了终末轴突变性的发生。在 HFHFD 模型中，机械性异常疼痛在疾病早期出现，但 6 个月时会缓解；热痛觉减退在轴突终末变性可检测到之前就已出现，且与 Sarm1 基因相关。

An increase in high-fat, high-fructose foods in people's diets has contributed to a dramatic increase in type 2 diabetes.

A groundbreaking study from Penn State unveils how birds structure their songs similarly to human language, using an ...

Just like ChatGPT and other generative language models train on human texts to create grammatically correct sentences, a new ...

Just like ChatGPT and other generative language models train on human texts to create grammatically correct sentences, a new ...

Researchers at Karolinska Institutet have discovered new insights into brain changes in Parkinson's disease using advanced ...

Three studies at the University of Zurich demonstrate that hypnosis alters activity in the large-scale functional networks of ...

A new study has revealed the clearest-ever picture of the surface chemistry of worm species that provides insights into how animals interact with their environment and each other. These discoveries ...