SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in ...

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A new study published in PLOS Genetics has identified an extreme mutational hotspot within the genome of Pseudomonas ...

Firefighters show higher rates of glioma-linked SBS42 mutational signatures associated with haloalkane exposure, suggesting ...

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. Purpose: Understanding the mutational landscape ...

During a Community Case Forum event in partnership with the Texas Society of Clinical Oncology, Natalie Vokes, MD, discussed trials of targeted agents for EGFR-mutant lung cancer.

A recent study has found that firefighters exposed to certain chemical compounds face a higher risk of developing gliomas, ...

Kei Sato was looking for his next big challenge five years ago when it smacked him — and the world — in the face. The ...

A recent study by Chinese scientists has revealed the intricate molecular machinery driving energy exchange within ...

Bispecific antibodies targeting multiple SARS-CoV-2 sites offer enhanced neutralization against emerging variants, advancing ...

Max Planck researchers discovered a 5,000-fold increase in the mutation rate in the genome of *Pseudomonas fluorescens*. The mutation regularly occurred in the promoter region of the *rpoS* gene and ...

Optimal therapeutic targeting of cancer involves clonal signals which are expressed within all cancer cellsGradalis applies a novel clinically relevant approach to determine clonal tumor mutation ...