The structure of chromatin at the nucleosome level inside cells is still incompletely understood. Here we present in situ electron cryotomography analyses of chromatin in both G1 and metaphase RPE-1 ...

The authors use elegant time-dependent microscopy reporter assays in immortalized tumor cell models to show that HIV-1 Vif causes a pseudo-metaphase arrest rather than a G2 arrest. The metaphase ...

Among the many marvels of life is the cell's ability to divide and thus enable organisms to grow and renew themselves. For ...

For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process ...

Version of Record: This is the final version of the article. Ghone et al show that HIV-1 Vif causes a pseudo-metaphase arrest rather than a G2 arrest. The metaphase arrest correlates with ...

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Scientists at EMBL have captured how human chromosomes fold into their signature rod shape during cell division, using a ...

To accomplish this, the DNA becomes highly compacted into the classic metaphase chromosomes that can be seen with a light microscope. Once a cell has divided, its chromosomes uncoil again.

It also touches on the implications of mitosis in healing and the potential consequences of its disruption, such as cancer or damage from radiation. Keywords mitosis, cell division, chromosomes, DNA, ...

Sleep and fertility are closely linked, as frequent snoring was associated with poor IVF outcomes and biochemical pregnancy ...