These ligands circulate throughout the body owing to weak affinity for HSGAG (heparan sulphate glycosaminoglycan), and they require α-klotho–β-klotho proteins as cofactors for their activity.

In the vast world of skincare, there are countless moisturizing ingredients to choose from. However, Hyaluronic acid and ...

Recombinant human hyaluronidase PH20 enabled rapid SC delivery by removing glycosaminoglycan hyaluronan blockage. Subcutaneous ocrelizumab (SC OCR) was found to be safe for patients with relapsing ...

The global submucosal lifting agent market is on a trajectory for remarkable growth, with projections indicating a compound ...

It contains a compound called polysulfated glycosaminoglycan (PSGAG). This stops the enzymes that can break down the cartilage that cushions your dog’s joints and promotes healthy joint fluid.

Tendons are designed to take tensile load, but excessive load can cause overuse tendinopathy. Overuse tendinopathy results in extensive changes to the cells and extracellular matrix, resulting in ...

Knee osteoarthritis (OA) is a common condition that causes pain and reduces the quality of life for many people. It also leads to high health and financial costs. Managing knee OA pain requires using ...

FIGURE 1. The interaction of the N- and C-terminus modulate gD receptor binding, notably the insertion of W294s side chain in the C-terminus into a crevice formed by L25 and Q27 in the N-terminus.

Teprotumumab (Tepezza), an insulin-like growth factor type 1 receptor antagonist, was approved for treatment of thyroid eye disease in 2020. Teprotumumab is administered intravenously every 3 weeks ...