A large-scale study has revealed the impact of germline variants on proteins in 10 cancer types. Scientists from the National ...

Researchers at Mayo Clinic's Center for Individualized Medicine have discovered a rare genetic variant that can directly ...

HealthDay News — A biomarker consisting primarily of microRNA-based germline biomarkers (mirSNPs), PROSTOX, is valid for predicting radiotherapy (RT)-induced genitourinary (GU) toxicity in patients ...

Germline development is the development of the cell lineage that gives rise to the reproductive cells, called gametes, of sexually reproducing organisms. Primordial germ cells, the founder cells ...

In this review, we seek to present a comprehensive summary of the frequency of germline genetic variants in hereditary cancer syndromes in patients from LAC. The data highlight relevant differences in ...

Inherited genes, present in all cells at birth, could well be the key to understanding cancer behavior. A recent study shows ...

For example, the PEAB helped develop a plain language explanation of variants of unknown significance (VUSs) and recommended clarifying the implications of having no identified somatic or germline ...

As a laboratory of developmental biology, our guiding interest is to comprehend how complex biological patterns can be assembled with stereotyped precision. This requires a detailed understanding of ...

Recent investigation focuses on the effects of BRCA1 and BRCA2 tumor pathogenic variants (tPVs) within the parameters of two ...

Pedro C. Barata, MD, MSc, discusses the use of darolutamide in patients with hormone-sensitive prostate cancer.

A major new study has revealed that the genes we inherit at birth play a much larger role in cancer than previously ...