Ramakrishnan, a distinguished structural biologist and Nobel Laureate in Chemistry (2009), is renowned for his groundbreaking w.

Recent cryo-electron microscopy (cryo-EM) and tomography data, also combined with crosslinking-mass spectrometry experiments, have uncovered detailed structural features of the coupling between a ...

Large macromolecules and subcellular structures have proven particularly good targets for imaging with cryo-EM. Some of the most exciting advances in the field have been in determining the 3D ...

Zhang Xinzheng at the Institute of Biophysics, Chinese Academy of Sciences, utilized cryo-electron microscopy (cryo-EM) along with their ... eEF3) to the ribosome as well as their dissociation ...

The major conformations of the ribosome and the elongation cycle ... Chinese Academy of Sciences, utilized cryo-electron microscopy (cryo-EM) along with their self-developed algorithm, GisSPA ...

Pipeline for particle picking in cryo-electron microscopy images using convolutional neural networks trained from positive and unlabeled examples. Also featuring micrograph and tomogram denoising with ...

Moreover, the study identified, for the first time, the fully rotated ribosome bound to the open form of eEF3. The researchers found that eEF3 binds to the ribosome early in translocation ...

Ribosomes getting stuck The team also made an important discovery about ribosome collisions—where one ribosome runs into another due to a tricky RNA segment or differences in speed, for example ...