Their pathogenesis is a consequence of hyperproliferation, hypersecretion and microRNA alterations in cholangiocytes. Here we evaluate the role of matrix metalloproteases (MMPs) in the hepatic ...

Bile duct inflammation and scarring, known as cholangiopathies, can disrupt bile flow, leading to liver damage and ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

2Dr. Li Dak-Sum Research Centre, the University of Hong Kong, Hong Kong 3Department of Surgery, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Hong Kong 4Department of Surgery, ...

Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type ...

During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, ...

Furthermore, UDCA protects cholangiocytes by promoting bile acid excretion, maintaining the integrity of bile ducts, and preventing bile acid-induced cellular damage. UDCA in DILI Treatment and ...