ABSTRACT: Cisplatin, a highly efficacious platinum-based anticancer agent, finds widespread application in the management of diverse malignant solid tumors, exhibiting commendable therapeutic outcomes ...

Ventus Therapeutics, a clinical-stage biopharmaceutical company with two novel small-molecule programs entering Phase 2 ...

相关文献： [1] Thornberry, N. A., & Lazebnik, Y. (1998). Caspases: enemies within. Science, 281(5381), 1312-1316. [2] Kumar, S. (2007). Caspase function in programmed cell death. Cell Death and ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...

这种结构使其能够特异性地与半胱氨酰天冬氨酸特异性蛋白酶（Caspases）结合，并在酶促反应下释放出强烈的荧光信号。 用途： 细胞凋亡研究：Z-VDVAD-AFC是研究细胞凋亡机制的重要工具。在细胞凋亡过程中，Caspases酶类扮演着至关重要的角色。Z-VDVAD-AFC能够特异性 ...

凋亡（Apoptosis）：细胞凋亡又称程序性细胞死亡，是 cfDNA 释放的重要途径。在生理和病理刺激下，细胞内一系列分子事件被触发，其中半胱天冬酶（Caspases）发挥关键作用。Caspases 激活半胱天冬酶激活的脱氧核糖核酸酶（caspase-activated DNase，CAD），CAD 将染色体 DNA ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

CSCs 如同肿瘤中的 “种子”，虽然数量稀少，却具备干细胞的特性，能够自我更新并分化成多种细胞谱系，促进肿瘤的生长、转移、复发，还对传统抗癌药物产生耐药性。因此，针对肺癌干细胞（LCSCs）的干预措施，有望成为肺癌治疗的有效策略。

1 Institute of Oncology, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, China 2 Internal Medicine, The Second People’s Hospital of Nantong, Nantong, China ...

This manuscript reports fundamental discoveries on how necrotic cells contribute to organ regeneration through apoptotic signalling to produce cells with non-lethal apoptotic caspase activity that ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...